Nasal extranodal peripheral NK/T-cell lymphoma treated by the protocol NK/T-cell high-dose-methotrexate L-asparaginase dexamethasone

NKT Cell Responses to B Cell Lymphoma

Natural killer T (NKT) cells are a unique subset of CD1d-restricted T lymphocytes that express characteristics of both T cells and natural killer cells. NKT cells mediate tumor immune-surveillance; however, NKT cells are numerically reduced and functionally impaired in lymphoma patients. Many hematologic malignancies express CD1d molecules and co-stimulatory proteins needed to induce anti-tumor...

Nasal type extranodal NK/T cell lymphoma diagnosed in a patient with rheumatoid arthritis under methotrexate.

Rheumatoid arthritis (RA) patients have increased risk of lymphoma which seems associated mainly with high inflammatory state and disease activity, but also with immunosuppressive agents or Epstein-Barr virus (EBV) infection. Many case reports describe lymphoproliferative lesions arising during methotrexate therapy, often EBV positive with possible regression after methotrexate withdrawal. The ...

Signaling for NKT cell development

New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src kinase, SAP may integrate a set of long-standing yet seemingly disparate observations characterizing NKT cell development. In fact, SAP-dependent signaling may underlie the development of multiple u...

T-cell lymphoma 229 EPSTEIN-BARR VIRUS DNA IN PERIPHERAL BLOOD AND EXTRANODAL NK/T-CELL LYMPHOMA, NASAL TYPE

Background: Peripheral blood of patients with extranodal NK/T-cell lymphoma, nasal type (ENKL) contains fragmented Epstein-Barr virus (EBV) DNA. Measurement of the circulating viral DNA load has been reported to be useful for diagnosis, monitoring and prognostication of the disease. However, there are two different subjects for analysis, plasma and mononuclear cells (MNC). It remains unclear wh...

Activation and Exacerbates NKT Cell 4-1BB Engagement Costimulates NKT Cell